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Sunday, December 23, 2012

Stephen Boppart: Spectroscopic OCT; Multimodal Microscopy; Cancer Imaging;Computing the best high-resolution 3-D tissue images

Spectroscopic OCT is an extension of OCT technology where not only the structural information, but also the spectroscopic information is retrieved. It is based on the principle that the bandwidth of a light source used in OCT is broad; therefore by using appropriate time-frequency analysis, a depth-resolved spectroscopy study can be performed. Spectroscopic OCT has at least two imaging targets: imaging spectral absorption and spectral scattering:

Multimodal Microscopy
Integrated optical coherence and multiphoton microscopy:

 Cancer Imaging
Cancer is one of the leading causes of death in the developed world. Currently, most forms of cancer are recognized when a tumor mass develops and becomes palpable by feel. However, recent advances in imaging and screening methods have led to the earlier detection of cancer which may lead to more effective therapy significantly reducing the morbidity and mortality rates attributed to cancer. Optical Coherence Tomography is capable of providing morphological information about the tissue on a micron scale resolution:

Computing the best high-resolution 3-D tissue images
University of Illinois engineers developed a method to computationally correct aberrations in three-dimensional tissue microscopy.
From left, postdoctoral researcher Steven Adie, professor P. Scott Carney, graduate students Adeel Ahmad and Benedikt Graf, and professor Stephen Boppart:

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